Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and rats.

نویسندگان

  • Anh-Hue T Tu
  • J Russell Lindsey
  • Trenton R Schoeb
  • Ada Elgavish
  • Huilan Yu
  • Kevin Dybvig
چکیده

The lysogenic bacteriophage MAV1 has been shown to be a virulence factor for the development of arthritis in rats infected with Mycoplasma arthritidis. In the present study, arthritis was evaluated by histopathologic examination to demonstrate that MAV1 is a virulence factor not only in the rat but also in the mouse. Specifically, the MAV1 lysogen 158L3-1 was more virulent than the nonlysogen strain 158 in DBA/2NCr, C3H/HeNCr, C3H/HeJ, and C3Smn.CB17-Prkdc(scid)/J mice, as well as in LEW rats.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 186 3  شماره 

صفحات  -

تاریخ انتشار 2002